Sugi Predict

Sugi Predict / Compounds / SCHEMBL2614922

SCHEMBL2614922

SCHEMBL2614922

Cc1cccnc1C1CC1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ OPRL1 P41146 7/20 0.59
▸ OPRM1 P35372 1/20 0.48
▸ TRPV1 Q8NER1 1/20 0.46
▸ NOS3 P29474 1/20 0.45
▸ NOS1 P29475 1/20 0.45
▸ NOS2 P35228 1/20 0.45
▸ DRD2 P14416 1/20 0.44
▸ DRD4 P21917 1/20 0.44
▸ DRD3 P35462 1/20 0.44
▸ HTR1A P08908 1/20 0.40
▸ SLC6A2 P23975 1/20 0.40
▸ SLC6A4 P31645 1/20 0.40
▸ PDE10A Q9Y233 1/20 0.38
▸ PLAU P00749 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ CYP2A6 P11509 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30137135 1.00 OPRL1 (0.59) OPRL1OPRM1TRPV1NOS3NOS1
SCHEMBL12818117 0.92 OPRL1 (0.54) OPRL1OPRM1TRPV1NOS3NOS1
SCHEMBL14925560 0.92 OPRL1 (0.56) OPRL1OPRM1TRPV1NOS3NOS1
SCHEMBL13450394 0.92 OPRL1 (0.60) OPRL1OPRM1TRPV1NOS3NOS1
SCHEMBL29210946 0.90 OPRL1 (0.61) OPRL1OPRM1TRPV1NOS3NOS1
SCHEMBL12818351 0.90 OPRL1 (0.61) OPRL1OPRM1TRPV1NOS3NOS1
SCHEMBL3212767 0.87 HTR1A (0.55) OPRL1OPRM1HTR1ASLC6A2SLC6A4
SCHEMBL20865902 0.87 OPRL1 (0.63) OPRL1OPRM1TRPV1DRD2DRD4
SCHEMBL30416668 0.87 OPRL1 (0.63) OPRL1OPRM1TRPV1DRD2DRD4
Hydrochloric Acid SCHEMBL27769607 0.85 HTR2C (0.54) OPRL1OPRM1HTR1ASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4273146-A1 TRICYCLIC COMPOUND AND USE THEREOF Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) 2023-11-08 — — EP disclosed
US-11771738-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-03 — — US disclosed
US-11771738-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-03 — — US disclosed
US-20230227472-A1 FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD (CN) 2023-07-20 — — US disclosed
WO-2021254529-A1 BICYCLIC COMPOUND 江苏先声药业有限公司 2021-12-23 — — WO disclosed
WO-2021222404-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN BIOTECH, INC. (US) 2021-11-04 — — WO disclosed
EP-3433234-B1 ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS MERCK SHARP & DOHME (US) 2021-10-27 — — EP disclosed
WO-2020200154-A1 A CLASS OF THIOPHENE FUSED N-HETEROCYCLIES, PREPARATION METHOD AND USE 上海凌达生物医药有限公司 2020-10-08 — — WO disclosed
CN-109715615-A Biaryl methyl heterocycles 蒙特利尔大学 2019-05-03 — — CN disclosed
CN-107922347-A New imide derivative and its purposes as medicine 田边三菱制药株式会社 2018-04-17 — — CN disclosed
EP-2379535-B1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES ARRAY BIOPHARMA INC (US) 2016-06-15 — — EP disclosed
US-20160031868-A1 BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS GILEAD SCIENCES, INC. 2016-02-04 — — US disclosed
US-20140296246-A1 BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS GILEAD SCIENCES, INC. (US) 2014-10-02 — — US disclosed
US-8785445-B2 7-phenoxychroman carboxylic acid derivatives ARRAY BIOPHARMA INC. (US) 2014-07-22 — — US disclosed
US-20130164259-A1 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF SCHERING CORPORATION 2013-06-27 — — US disclosed
EP-2594554-A1 BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Dainippon Sumitomo Pharma Co., Ltd. (JP) 2013-05-22 — — EP disclosed
US-20130116227-A1 BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2013-05-09 — — US disclosed
US-20130116227-A1 BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2013-05-09 — — US disclosed
US-20120101103-A1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES ARRAY BIOPHARMA INC. (US) 2012-04-26 — — US disclosed
WO-2012008435-A1 BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 大日本住友製薬株式会社 (JP) 2012-01-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130164259-A1 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF ZC3HAV1, BAZ2A, HAVCR2 OPRL1 2643/4885OPRM1 1536/4885TRPV1 1494/4885
US-20130116227-A1 BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF MC2R, NR3C2, REN OPRL1 328/4885OPRM1 611/4885TRPV1 2298/4885
US-20160031868-A1 BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRD1 OPRL1 3907/4885OPRM1 4100/4885TRPV1 3300/4885
US-20230227472-A1 FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF KRAS, NRAS, WEE1 OPRL1 4549/4885OPRM1 4666/4885TRPV1 2560/4885
US-11771738-B2 Endoparasitic depsipeptides VIP, PREP, VIPR1 OPRL1 760/4885OPRM1 2686/4885TRPV1 281/4885
US-20140296246-A1 BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRD1 OPRL1 3907/4885OPRM1 4100/4885TRPV1 3300/4885
US-20120101103-A1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES PTGDR2, PTGDR, HRH2 OPRL1 1545/4885OPRM1 2639/4885TRPV1 1168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.