Sugi Predict

Sugi Predict / Compounds / SCHEMBL2459871

SCHEMBL2459871

SCHEMBL2459871

NC(=O)c1ccccc1COc1cccc(C2=NC(C3=CC=C3)=C3C=NC=C[N+]23N)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CFD P00746 1/20 0.33
▸ HIF1A Q16665 4/20 0.33
▸ PARP10 Q53GL7 3/20 0.33
▸ PARP15 Q460N3 2/20 0.33
▸ PLA2G10 O15496 1/20 0.32
▸ PLA2G2A P14555 1/20 0.32
▸ SIRT2 Q8IXJ6 2/20 0.32
▸ PARP14 Q460N5 1/20 0.32
▸ DYRK3 O43781 1/20 0.31
▸ MAP4K4 O95819 1/20 0.31
▸ PIM1 P11309 1/20 0.31
▸ RPS6KB1 P23443 1/20 0.31
▸ CSNK2A1 P68400 1/20 0.31
▸ PKN2 Q16513 1/20 0.31
▸ PIM3 Q86V86 1/20 0.31
▸ BRSK1 Q8TDC3 1/20 0.31
▸ AURKB Q96GD4 1/20 0.31
▸ HIPK2 Q9H2X6 1/20 0.31
▸ CLK4 Q9HAZ1 1/20 0.31
▸ MKNK2 Q9HBH9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460721 0.86 PTGER1 (0.35) CFDPTGER4
SCHEMBL2460739 0.86 EGFR (0.38) PARP10PARP15PARP14MEN1KMT2A
SCHEMBL2460704 0.86 PARP10 (0.31) PARP10
SCHEMBL2460166 0.85 MRGPRX4 (0.42) CFDPARP10PARP15PARP14NPC1
SCHEMBL2458203 0.84 MAOB (0.35) NPC1RAB9AMEN1KMT2ARECQL
SCHEMBL2463322 0.84 NR1H4 (0.36) CFDNPC1RAB9ANR4A2MRGPRX4
SCHEMBL2459795 0.84 GRIN1 (0.33) —
SCHEMBL2462400 0.84 IGF1R (0.35) MEN1KMT2A
SCHEMBL2460755 0.83 CD274 (0.30) CFD
SCHEMBL2459956 0.83 CFD (0.30) CFD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 CFD 4850/4885HIF1A 1809/4885PARP10 3128/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 CFD 4850/4885HIF1A 1809/4885PARP10 3128/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 CFD 4850/4885HIF1A 1809/4885PARP10 3128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.