Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 16/20 | 0.51 |
| ▸ | THRB | P10828 | 16/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28664590 | 0.93 | THRB (0.52) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600247 | 0.91 | THRB (0.54) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600250 | 0.90 | THRA (0.50) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600238 | 0.90 | THRA (0.52) | THRATHRBCYP2C8CYP2C9NPBWR1 | |
| SCHEMBL24600346 | 0.88 | THRA (0.48) | THRATHRBCYP2C8CYP2C9NPBWR1 | |
| SCHEMBL24600355 | 0.88 | THRA (0.48) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600270 | 0.88 | THRB (0.49) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600362 | 0.86 | THRA (0.54) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600240 | 0.86 | THRB (0.52) | THRATHRBCYP2C8CYP2C9NPC1 | |
| SCHEMBL24600350 | 0.86 | THRA (0.54) | THRATHRBCYP2C8CYP2C9NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273139-A1 | 2-PYRIDONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | KPC Pharmaceuticals, Inc. (CN) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022143574-A1 | 2-PYRIDONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | 昆药集团股份有限公司 | 2022-07-07 | — | — | WO | disclosed |