Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.45 |
| ▸ | MTOR | P42345 | 10/20 | 0.45 |
| ▸ | RICTOR | Q6R327 | 4/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.45 |
| ▸ | MAPKAP1 | Q9BPZ7 | 4/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248275 | 0.79 | PIK3CA (0.44) | PIK3CAMTORMAP3K12BTK | |
| SCHEMBL243086 | 0.72 | PIK3CA (0.48) | PIK3CAMTORKMT2APIK3R1PIK3CD | |
| SCHEMBL9695483 | 0.71 | ALDH1A1 (0.61) | KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL2558872 | 0.71 | DHFR (0.60) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL26523088 | 0.71 | BCL6 (0.47) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL24196192 | 0.70 | KDM4E (0.69) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL1334257 | 0.69 | CNR2 (0.46) | PIK3CA | |
| SCHEMBL1334256 | 0.69 | CNR2 (0.46) | PIK3CA | |
| SCHEMBL23365156 | 0.68 | CYP3A4 (0.79) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL26647400 | 0.67 | PIK3CA (0.56) | PIK3CAMTORKMT2APIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588473-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS PIK3 -DELTA INHIBITORS | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| US-20130079342-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. | 2013-03-28 | — | — | US | disclosed |
| US-20130079342-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. | 2013-03-28 | — | — | US | disclosed |
| US-20130079342-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. | 2013-03-28 | — | — | US | disclosed |
| WO-2012003264-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS PIK3 -DELTA INHIBITORS | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012003264-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS PIK3 -DELTA INHIBITORS | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079342-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | PIK3CA 26/4885MTOR 294/4885RICTOR 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.