Sugi Predict

Sugi Predict / Compounds / SCHEMBL2460150

SCHEMBL2460150

SCHEMBL2460150

N[N+]12C=CN=CC1=C(C1=CC=C1)N=C2c1cccc(OCc2ccc(OC(F)F)cc2)c1

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.37
▸ MRGPRX4 Q96LA9 1/20 0.34
▸ PDE4B Q07343 7/20 0.33
▸ PDE4A P27815 4/20 0.33
▸ PDE4C Q08493 4/20 0.33
▸ PDE4D Q08499 4/20 0.33
▸ PDE5A O76074 1/20 0.32
▸ GRIN1 Q05586 1/20 0.30
▸ GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2458043 0.93 IGF1R (0.37) IGF1RMRGPRX4PDE4BPDE4APDE4C
SCHEMBL2457080 0.90 MEN1 (0.39) IGF1RMRGPRX4
SCHEMBL2460741 0.89 SMPD1 (0.36) IGF1RMRGPRX4
SCHEMBL2460200 0.89 MAOB (0.37) IGF1RMRGPRX4
SCHEMBL2459646 0.88 MRGPRX4 (0.34) MRGPRX4PDE4BPDE4APDE4CPDE4D
SCHEMBL2457790 0.88 MAOB (0.38) —
SCHEMBL2460218 0.88 NR4A2 (0.38) IGF1R
SCHEMBL2459584 0.87 IGF1R (0.38) IGF1RPDE4B
SCHEMBL2460592 0.86 PPARG (0.31) —
SCHEMBL2460484 0.86 F9 (0.38) IGF1RMRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885MRGPRX4 1767/4885PDE4B 2775/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885MRGPRX4 1767/4885PDE4B 2775/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885MRGPRX4 1767/4885PDE4B 2775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.