Sugi Predict

Sugi Predict / Compounds / SCHEMBL2460484

SCHEMBL2460484

SCHEMBL2460484

N[N+]12C=CN=CC1=C(C1=CC=C1)N=C2c1cccc(OCc2ccc(F)c(F)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ F9 P00740 3/20 0.38
▸ F10 P00742 3/20 0.38
▸ IGF1R P08069 1/20 0.35
▸ ALOX5 P09917 1/20 0.34
▸ FFAR1 O14842 3/20 0.32
▸ ADORA2A P29274 1/20 0.32
▸ MRGPRX4 Q96LA9 2/20 0.32
▸ PPARA Q07869 4/20 0.31
▸ APLNR P35414 1/20 0.31
▸ MAOB P27338 2/20 0.31
▸ PPARD Q03181 3/20 0.31
▸ MAOA P21397 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ PPARG P37231 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ NCOA2 Q15596 1/20 0.30
▸ NCOA1 Q15788 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2459539 0.92 MRGPRX4 (0.30) MRGPRX4
SCHEMBL2457080 0.91 MEN1 (0.39) F9F10IGF1RMRGPRX4MAOB
SCHEMBL2459633 0.90 MAOB (0.39) F9F10IGF1RMRGPRX4MAOB
SCHEMBL2462348 0.89 IGF1R (0.34) F9F10IGF1RMRGPRX4MAOB
SCHEMBL2460218 0.89 NR4A2 (0.38) F9F10IGF1RMAOBMAOA
SCHEMBL2461458 0.89 MEN1 (0.37) IGF1RMEN1MAPTKMT2A
SCHEMBL2459470 0.89 MEN1 (0.33) MEN1KMT2A
SCHEMBL2461522 0.89 ALOX5 (0.34) ALOX5MRGPRX4MAOBMAOA
SCHEMBL2461743 0.89 NR4A2 (0.39) F9F10IGF1RMAOBMAOA
SCHEMBL2460741 0.88 SMPD1 (0.36) F9F10IGF1RALOX5MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 F9 4236/4885F10 3668/4885IGF1R 1/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 F9 4236/4885F10 3668/4885IGF1R 1/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 F9 4236/4885F10 3668/4885IGF1R 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.