Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.39 |
| ▸ | IGF1R | P08069 | 5/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460247 | 0.93 | JAK2 (0.37) | ADAM17IGF1RJAK2KCNH2BTK | |
| SCHEMBL2462980 | 0.91 | ADAM17 (0.33) | ADAM17IGF1RJAK2JAK1KCNH2 | |
| SCHEMBL2457720 | 0.86 | IGF1R (0.34) | ADAM17IGF1RJAK2JAK1KCNH2 | |
| SCHEMBL2458133 | 0.86 | IGF1R (0.41) | IGF1RJAK2JAK1HDAC4F10 | |
| SCHEMBL2460551 | 0.84 | IGF1R (0.48) | IGF1RJAK2JAK1KCNH2BTK | |
| SCHEMBL5115303 | 0.84 | IGF1R (0.35) | ADAM17IGF1RJAK2JAK1KCNH2 | |
| SCHEMBL2460164 | 0.84 | ACACB (0.35) | ADAM17IGF1RJAK2JAK1F10 | |
| SCHEMBL2457374 | 0.84 | IGF1R (0.43) | IGF1RJAK2JAK1KCNH2F10 | |
| SCHEMBL2463470 | 0.83 | IGF1R (0.51) | IGF1RJAK2JAK1HDAC4F10 | |
| SCHEMBL5109184 | 0.83 | IGF1R (0.34) | ADAM17IGF1RJAK2JAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-B1 | IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS | OSI PHARM INC (US) | 2011-09-21 | — | — | EP | disclosed |