Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dihydrocodeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 12/20 | 0.77 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.74 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrocodeine SCHEMBL12402838 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL13380391 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL18569649 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL12960899 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL159237 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL10440393 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL12402837 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL6064584 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL6123622 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL19615457 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20846 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| EP-4714444-A1 | PREPARATION FOR AND USE OF CANNABIDIOL DERIVATIVE DRUGS | Changchun Institute Of Applied Chemistry Chinese Academy Of Sciences (CN) | 2026-03-25 | — | — | EP | claimed |
| US-12564597-B2 | Ibogaine analogs as therapeutics for neurological and psychiatric disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE OF NEW YORK (US) | 2026-03-03 | — | — | US | claimed |
| EP-3355885-B1 | POLYSUBUNIT OPIOID PRODRUGS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS INC (US) | 2026-02-25 | — | — | EP | claimed |
| EP-4100010-B1 | NITROXIDE COMPOUNDS FOR USE IN THE TREATMENT OF OPIOID-INDUCED RESPIRATORY DEPRESSION (OIRD) | UNIV CASE WESTERN RESERVE (US) | 2026-01-07 | — | — | EP | claimed |
| WO-2025260160-A1 | SILICON-SULFUR BATTERY AND CORRESPONDING METHOD FOR ASSEMBLING THE BATTERY | FAGUNDES RODRIGO DE LIMA (BR) | 2025-12-26 | — | — | WO | claimed |
| EP-4665758-A1 | TREATMENT OF OPIOD-INDUCED PAIN | H. Lundbeck A/S (DK) | 2025-12-24 | — | — | EP | claimed |
| US-20250319074-A1 | TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME | UNIV EAST CAROLINA (US) | 2025-10-16 | — | — | US | claimed |
| US-4844907-A | COMBINATION OF NARCOTIC AND NON-STEROIDAL ANTI-INFLAMMATORY | EUROCELTIQUE, S.A. (LU) | 1989-07-04 | — | — | US | claimed |
| US-4834965-A | Controlled release pharmaceutical composition | EUROCELTIQUE, S.A. (LU) | 1989-05-30 | — | — | US | claimed |
| US-4834984-A | SOLID MATRIX OF HYDROXYALKYL CELLULOSE AND ALIPHATIC ALCOHOL | EUROCELTIQUE S.A. (LU) | 1989-05-30 | — | — | US | claimed |
| EP-0294103-A1 | A sustained-release preparation and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1988-12-07 | — | — | EP | claimed |
| EP-0249347-A2 | Controlled release dihydrocodeine composition | Euroceltique S.A. (LU) | 1987-12-16 | — | — | EP | claimed |
| EP-0220805-A2 | Multiphase tablet and process for the preparation thereof | Euroceltique S.A. (LU) | 1987-05-06 | — | — | EP | claimed |
| EP-0214735-A1 | Controlled release pharmaceutical composition | Euroceltique S.A. (LU) | 1987-03-18 | — | — | EP | claimed |
| EP-0185420-A1 | Dihydrocodeine/ibuprofen pharmaceutical compositions and method | Arnold, John D. (US) | 1986-06-25 | — | — | EP | claimed |
| US-4571400-A | ANALGESIC | BELLEVIEW PHARMACEUTICAL, INC. | 1986-02-18 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |