Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dihydrocodeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 12/20 | 0.77 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.74 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrocodeine SCHEMBL13380391 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL159237 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL12646336 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL18569649 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL17284442 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL14516219 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL13154681 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL12402838 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL6064584 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Dihydrocodeine SCHEMBL19615457 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10449190-B2 | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof | THOTTATHIL JOHN K (US) | 2019-10-22 | — | — | US | disclosed |
| US-20170196851-A1 | Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other Gras- Based Prodrugs Of Opioids And Uses Thereof | THOTTATHIL JOHN K (US) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10449190-B2 | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof | OPRD1, OPRK1, OPRM1 | OPRM1 3/4885OPRD1 1/4885OPRK1 2/4885 |
| US-20170196851-A1 | Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other Gras- Based Prodrugs Of Opioids And Uses Thereof | OPRD1, OPRK1, OPRM1 | OPRM1 3/4885OPRD1 1/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.