Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22790807 | 0.84 | ALDH1A1 (0.65) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL27668385 | 0.82 | ALDH1A1 (0.62) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL23696647 | 0.79 | ALDH1A1 (0.59) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL8254073 | 0.79 | ALDH1A1 (0.74) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL8529470 | 0.77 | ALDH1A1 (1.00) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL12717312 | 0.77 | ALDH1A1 (0.71) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL26464403 | 0.77 | NPC1 (0.91) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL18234102 | 0.76 | SIGMAR1 (0.74) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL10131833 | 0.76 | ALDH1A1 (0.69) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL349502 | 0.76 | ALDH1A1 (0.69) | ALDH1A1NPC1TP53KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |