Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019143 | 0.70 | CYP19A1 (0.53) | KDM4EALDH1A1HSD17B10TDP1ALOX5 | |
| SCHEMBL86321 | 0.70 | CYP19A1 (0.53) | KDM4EALDH1A1HSD17B10TDP1ALOX5 | |
| SCHEMBL16836537 | 0.70 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10PARP1 | |
| SCHEMBL852241 | 0.70 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10PARP1 | |
| SCHEMBL28262113 | 0.67 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10PARP1 | |
| SCHEMBL1478086 | 0.67 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10PARP1 | |
| SCHEMBL378548 | 0.67 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10PARP1 | |
| SCHEMBL6434380 | 0.67 | MAPT (0.46) | KDM4EGPR3ALDH1A1HSD17B10NPC1 | |
| SCHEMBL27619154 | 0.66 | KDM4E (0.38) | KDM4EGPR3ALDH1A1HSD17B10PARP1 | |
| SCHEMBL27619538 | 0.66 | KDM4E (0.38) | KDM4EGPR3ALDH1A1HSD17B10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237617-A1 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | PELLICCIARI ROBERTO | 2011-09-29 | — | — | US | disclosed |
| US-7825129-B2 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PELLICCIARI ROBERTO | 2010-11-02 | — | — | US | disclosed |
| EP-1464646-B1 | Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp | PELLICCIARI ROBERTO (IT) | 2009-09-30 | — | — | EP | disclosed |
| US-20060094746-A1 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PELLICCIARI ROBERTO | 2006-05-04 | — | — | US | disclosed |
| US-6989388-B2 | Thieno[2,3-c]iosquinolines for use as inhibitors of PARP | Pellicciari, Roberto (IT) | 2006-01-24 | — | — | US | disclosed |
| EP-1464646-A1 | Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp | SMITHKLINE BEECHAM PLC (GB) | 2004-10-06 | — | — | EP | disclosed |
| US-20040082789-A1 | Thieno[2,3-c]iosquinolines for use as inhibitors of parp | MORONI, FLAVIO (IT) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237617-A1 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | PARP1, PARP2, PARP3 | KDM4E 754/4885GPR3 2478/4885ALDH1A1 136/4885 |
| US-20040082789-A1 | Thieno[2,3-c]iosquinolines for use as inhibitors of parp | PARP1, PARP2, PARP12 | KDM4E 3808/4885GPR3 1621/4885ALDH1A1 1365/4885 |
| US-20060094746-A1 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PARP1, PARP2, PARP3 | KDM4E 754/4885GPR3 2478/4885ALDH1A1 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.