Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21530458 | 0.88 | PIK3CA (0.38) | NNMTPIK3CAMTORGPBAR1SLC6A3 | |
| SCHEMBL12343374 | 0.86 | PIK3CA (0.40) | NNMTPIK3CAMTORGPBAR1SLC6A3 | |
| SCHEMBL30645693 | 0.86 | PIK3CA (0.40) | NNMTPIK3CAMTORGPBAR1SLC6A3 | |
| SCHEMBL16441418 | 0.83 | ALDH1A1 (0.41) | NNMTGPBAR1GABRPGABRDGABRA1 | |
| SCHEMBL16804950 | 0.83 | LRRK2 (0.38) | PIK3CAMTORGPBAR1KCNQ3KCNQ2 | |
| SCHEMBL30567605 | 0.83 | PIK3CA (0.38) | PIK3CAMTORGPBAR1SLC6A3MLYCD | |
| SCHEMBL8282929 | 0.83 | PIK3CA (0.38) | PIK3CAMTORGPBAR1SLC6A3MLYCD | |
| SCHEMBL22305953 | 0.81 | GPBAR1 (0.39) | NNMTGPBAR1GABRPGABRDGABRA1 | |
| SCHEMBL16108516 | 0.80 | PIK3CA (0.39) | PIK3CAMTORGPBAR1SLC6A3MEN1 | |
| SCHEMBL31220031 | 0.80 | PIK3CA (0.39) | PIK3CAMTORGPBAR1SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807261-B1 | PYRIDINYL PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-13 | — | — | EP | disclosed |