Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30567605 | 1.00 | PIK3CA (0.38) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL12343374 | 0.87 | PIK3CA (0.40) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL30645693 | 0.87 | PIK3CA (0.40) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL21530458 | 0.86 | PIK3CA (0.38) | PIK3CAMTORSLC6A3GPBAR1PKM | |
| SCHEMBL18490164 | 0.84 | MEN1 (0.43) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL16108516 | 0.84 | PIK3CA (0.39) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL31220031 | 0.84 | PIK3CA (0.39) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL24612469 | 0.83 | NNMT (0.40) | PIK3CAMTORSLC6A3MEN1KMT2A | |
| SCHEMBL16804950 | 0.81 | LRRK2 (0.38) | PIK3CAMTORMEN1KMT2AALDH1A1 | |
| SCHEMBL18529458 | 0.78 | MEN1 (0.52) | MEN1KMT2AALDH1A1LRRK2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005084439-A1 | 2-PYRIDINYL[7-(SUBSTITUTED-PYRIDIN-4-YL) PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]METHANONES | DOV PHARMACEUTICAL, INC. (US) | 2005-09-15 | — | — | WO | disclosed |