Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.77 |
| ▸ | ABL1 | P00519 | 5/20 | 0.64 |
| ▸ | ABL2 | P42684 | 5/20 | 0.64 |
| ▸ | PRKCA | P17252 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2458457 | 0.87 | EGFR (1.00) | EGFRABL1ABL2PRKCANPC1 | |
| SCHEMBL2461249 | 0.81 | EGFR (1.00) | EGFRABL1ABL2PRKCAMAPT | |
| SCHEMBL10957753 | 0.79 | HPGD (0.59) | EGFRNPC1HPGDRAB9AMEN1 | |
| SCHEMBL2460994 | 0.79 | EGFR (1.00) | EGFRABL1ABL2PRKCARAB9A | |
| SCHEMBL2458392 | 0.79 | EGFR (0.78) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2458367 | 0.74 | EGFR (0.76) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2459209 | 0.71 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL5568144 | 0.71 | HTT (0.65) | EGFRNPC1HPGDRAB9AMEN1 | |
| SCHEMBL2461152 | 0.70 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2461566 | 0.69 | EGFR (0.68) | EGFRABL1ABL2PRKCAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | claimed |
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | disclosed |