Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.68 |
| ▸ | ABL1 | P00519 | 5/20 | 0.63 |
| ▸ | ABL2 | P42684 | 5/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460975 | 0.82 | EGFR (0.73) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461532 | 0.81 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461344 | 0.77 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2458457 | 0.76 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL3794273 | 0.75 | MAPK1 (0.64) | MEN1KMT2AGAA | |
| SCHEMBL2461045 | 0.73 | EGFR (0.67) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL3802570 | 0.73 | PIP4K2C (0.53) | EGFRMEN1KMT2AGAA | |
| SCHEMBL2461249 | 0.72 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL5357967 | 0.71 | KMT2A (0.57) | EGFRMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL7496318 | 0.70 | EGFR (0.97) | EGFRABL1ABL2PRKCAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | claimed |
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | disclosed |