Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | ABL1 | P00519 | 5/20 | 0.66 |
| ▸ | ABL2 | P42684 | 5/20 | 0.66 |
| ▸ | PRKCA | P17252 | 1/20 | 0.66 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.53 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460975 | 0.84 | EGFR (0.73) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461566 | 0.81 | EGFR (0.68) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461344 | 0.80 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2458392 | 0.77 | EGFR (0.78) | EGFRABL1ABL2PRKCATTBK1 | |
| SCHEMBL2461138 | 0.77 | EGFR (0.70) | EGFRABL1ABL2PRKCA | |
| SCHEMBL29406611 | 0.76 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2463632 | 0.76 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461045 | 0.75 | EGFR (0.67) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461152 | 0.74 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2461249 | 0.74 | EGFR (1.00) | EGFRABL1ABL2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | claimed |
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | disclosed |
| WO-1998043973-A1 | INTERMEDIATE PRODUCTS AND METHOD FOR THE PRODUCTION OF PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 1998-10-08 | — | — | WO | disclosed |