Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.49 |
| ▸ | TYK2 | P29597 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 7/20 | 0.43 |
| ▸ | RET | P07949 | 9/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615378 | 0.88 | JAK2 (0.46) | JAK2JAK1TYK2KITRET | |
| SCHEMBL24615298 | 0.88 | JAK2 (0.40) | JAK2JAK1TYK2KITRET | |
| SCHEMBL24615295 | 0.88 | JAK2 (0.40) | JAK2JAK1TYK2KITRET | |
| SCHEMBL24615459 | 0.87 | JAK1 (0.43) | JAK2JAK1TYK2KITRET | |
| SCHEMBL24615370 | 0.87 | TYK2 (0.46) | JAK2JAK1TYK2KITJAK3 | |
| SCHEMBL24615410 | 0.86 | TYK2 (0.45) | JAK2JAK1TYK2KITJAK3 | |
| SCHEMBL24615557 | 0.86 | JAK1 (0.50) | JAK2JAK1TYK2KITRET | |
| SCHEMBL24615603 | 0.85 | JAK1 (0.43) | JAK2JAK1TYK2KITRET | |
| SCHEMBL29772821 | 0.84 | JAK1 (0.40) | JAK2JAK1TYK2KITRET | |
| SCHEMBL29772862 | 0.84 | JAK1 (0.44) | JAK2JAK1TYK2KITRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117098763-A | TYK2 inhibitors | 渤健马萨诸塞州股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| EP-4274832-A1 | TYK2 INHIBITORS | Biogen MA Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |