Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.45 |
| ▸ | JAK1 | P23458 | 13/20 | 0.45 |
| ▸ | JAK2 | O60674 | 12/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772862 | 0.89 | JAK1 (0.44) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615583 | 0.89 | JAK1 (0.44) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615407 | 0.89 | TYK2 (0.46) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL24615408 | 0.88 | TYK2 (0.42) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL24615426 | 0.88 | TYK2 (0.42) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615367 | 0.88 | TYK2 (0.42) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615414 | 0.87 | JAK1 (0.42) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615358 | 0.87 | KIT (0.46) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615433 | 0.86 | JAK2 (0.49) | TYK2JAK1JAK2JAK3KIT | |
| SCHEMBL24615448 | 0.85 | JAK1 (0.41) | TYK2JAK1JAK2JAK3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |