Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 3/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615583 | 1.00 | JAK1 (0.44) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL29772821 | 0.90 | JAK1 (0.40) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615598 | 0.90 | JAK1 (0.42) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615410 | 0.89 | TYK2 (0.45) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615420 | 0.88 | TYK2 (0.41) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615424 | 0.87 | TYK2 (0.41) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615595 | 0.87 | KIT (0.51) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615407 | 0.86 | TYK2 (0.46) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615600 | 0.86 | JAK1 (0.40) | JAK1JAK2TYK2JAK3KIT | |
| SCHEMBL24615408 | 0.85 | TYK2 (0.42) | JAK1JAK2TYK2JAK3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117098763-A | TYK2 inhibitors | 渤健马萨诸塞州股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| EP-4274832-A1 | TYK2 INHIBITORS | Biogen MA Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |