Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | TYMS | P04818 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24616607 | 0.77 | PARP1 (0.38) | CHEK1PARP1PRMT5WDR77 | |
| SCHEMBL19204854 | 0.76 | AR (0.35) | CHEK1AR | |
| SCHEMBL14737657 | 0.73 | TRPA1 (0.35) | — | |
| SCHEMBL25235149 | 0.67 | NOS1 (0.41) | PARP1 | |
| SCHEMBL23577814 | 0.66 | IDO1 (0.41) | IDO1 | |
| SCHEMBL29909529 | 0.66 | IDO1 (0.41) | IDO1 | |
| SCHEMBL19250509 | 0.63 | CHEK1 (0.35) | CHEK1IDO1 | |
| SCHEMBL26615075 | 0.63 | AR (0.45) | PARP1PRMT5TYMSAR | |
| SCHEMBL31358037 | 0.62 | — | — | |
| SCHEMBL29937099 | 0.62 | MAP2 (0.42) | PARP1IDO1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148422-A1 | BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2022-07-14 | — | — | WO | disclosed |