Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6523609 | 0.86 | CYP2C19 (0.44) | EPHX1L3MBTL1CYP2C19NAAAHTT | |
| SCHEMBL6516003 | 0.86 | CYP2C19 (0.44) | EPHX1L3MBTL1CYP2C19NAAAHTT | |
| SCHEMBL6514416 | 0.84 | NAAA (0.41) | EPHX1CYP2C19NAAAHTTTHRB | |
| Succinic Acid SCHEMBL28225254 | 0.84 | SMN1; SMN2 (0.46) | EPHX1L3MBTL1CYP2C19NAAAHTT | |
| Malonic Acid SCHEMBL28101171 | 0.84 | EPHX1 (0.46) | EPHX1L3MBTL1CYP2C19NAAAHTT | |
| SCHEMBL29676987 | 0.83 | LMNA (0.39) | EPHX1L3MBTL1CYP2C19NAAAPTGDR2 | |
| SCHEMBL6513751 | 0.83 | EPHX1 (0.37) | EPHX1L3MBTL1CYP2C19NAAAHTT | |
| SCHEMBL24616788 | 0.83 | LMNA (0.39) | EPHX1L3MBTL1CYP2C19NAAAPTGDR2 | |
| SCHEMBL6523997 | 0.83 | EPHX1 (0.37) | EPHX1L3MBTL1CYP2C19NAAAHTT | |
| Bicarbonate SCHEMBL28128083 | 0.83 | EPHX1 (0.45) | EPHX1L3MBTL1CYP2C19NAAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4200275-A2 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | Sitryx Therapeutics Limited (GB) | 2023-06-28 | — | — | EP | disclosed |
| WO-2022038365-A9 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | SITRYX THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022038365-A9 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | SITRYX THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022038365-A2 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LIMITED (GB) | 2022-02-24 | — | — | WO | disclosed |