Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778487 | 1.00 | ROCK2 (0.42) | ROCK2ROCK1MAPK1EGLN1METAP2 | |
| SCHEMBL29778373 | 0.89 | ROCK2 (0.41) | ROCK2ROCK1MAPK1EGLN1METAP2 | |
| SCHEMBL29135939 | 0.89 | ROCK2 (0.41) | ROCK2ROCK1MAPK1EGLN1METAP2 | |
| SCHEMBL24617619 | 0.89 | ROCK2 (0.41) | ROCK2ROCK1MAPK1EGLN1METAP2 | |
| SCHEMBL29778498 | 0.88 | ROCK2 (0.51) | ROCK2ROCK1MAPK1EGLN1GRM2 | |
| SCHEMBL24617030 | 0.88 | ROCK2 (0.51) | ROCK2ROCK1MAPK1EGLN1GRM2 | |
| SCHEMBL29778459 | 0.83 | ROCK2 (0.39) | ROCK2ROCK1MAPK1METAP2GRM2 | |
| SCHEMBL24617616 | 0.83 | MAPK1 (0.40) | ROCK2ROCK1MAPK1EGLN1METAP2 | |
| SCHEMBL24616945 | 0.81 | ROCK2 (0.51) | ROCK2ROCK1MAPK1EGLN1METAP2 | |
| SCHEMBL29778415 | 0.81 | ROCK2 (0.51) | ROCK2ROCK1MAPK1EGLN1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |