Sugi Predict

Sugi Predict / Compounds / SCHEMBL29778487

SCHEMBL29778487

SCHEMBL29778487

CNC(=O)c1cc(F)cc(Cn2ccc3cc(-c4cn[nH]c4Cl)ccc3c2=O)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ROCK2 O75116 1/20 0.42
▸ ROCK1 Q13464 1/20 0.42
▸ MAPK1 P28482 1/20 0.39
▸ EGLN1 Q9GZT9 1/20 0.37
▸ METAP2 P50579 1/20 0.36
▸ GRM2 Q14416 1/20 0.35
▸ KLKB1 P03952 1/20 0.34
▸ MAP4K1 Q92918 1/20 0.34
▸ WDR5 P61964 2/20 0.34
▸ LMNA P02545 3/20 0.33
▸ TP53 P04637 1/20 0.33
▸ RXFP1 Q9HBX9 1/20 0.33
▸ STAT6 P42226 1/20 0.33
▸ PARP1 P09874 1/20 0.33
▸ TNIK Q9UKE5 1/20 0.33
▸ BRD4 O60885 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ GRK2 P25098 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24617035 1.00 ROCK2 (0.42) ROCK2ROCK1MAPK1EGLN1METAP2
SCHEMBL29778373 0.89 ROCK2 (0.41) ROCK2ROCK1MAPK1EGLN1METAP2
SCHEMBL29135939 0.89 ROCK2 (0.41) ROCK2ROCK1MAPK1EGLN1METAP2
SCHEMBL24617619 0.89 ROCK2 (0.41) ROCK2ROCK1MAPK1EGLN1METAP2
SCHEMBL29778498 0.88 ROCK2 (0.51) ROCK2ROCK1MAPK1EGLN1GRM2
SCHEMBL24617030 0.88 ROCK2 (0.51) ROCK2ROCK1MAPK1EGLN1GRM2
SCHEMBL29778459 0.83 ROCK2 (0.39) ROCK2ROCK1MAPK1METAP2GRM2
SCHEMBL24617616 0.83 MAPK1 (0.40) ROCK2ROCK1MAPK1EGLN1METAP2
SCHEMBL24616945 0.81 ROCK2 (0.51) ROCK2ROCK1MAPK1EGLN1METAP2
SCHEMBL29778415 0.81 ROCK2 (0.51) ROCK2ROCK1MAPK1EGLN1METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF Genosco Inc. 2024-11-14 — — US claimed
CN-117136186-A Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof 盖诺斯克公司 2023-11-28 — — CN claimed
EP-4274825-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2023-11-15 — — EP claimed
WO-2022150381-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2022-07-14 — — WO claimed
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF Genosco Inc. 2024-11-14 — — US disclosed
CN-117136186-A Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof 盖诺斯克公司 2023-11-28 — — CN disclosed
EP-4274825-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2023-11-15 — — EP disclosed
WO-2022150381-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2022-07-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF ROCK2, ROCK1, MYLK3 ROCK2 1/4885ROCK1 2/4885MAPK1 146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.