Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CD74 | P04233 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779107 | 1.00 | IDO1 (0.48) | IDO1MAPK10YTHDC1ABHD6MAPK8 | |
| SCHEMBL29136068 | 0.88 | EGLN1 (0.53) | YTHDC1EGLN1 | |
| SCHEMBL30656517 | 0.88 | EGLN1 (0.53) | YTHDC1EGLN1 | |
| SCHEMBL29136034 | 0.87 | EGLN1 (0.50) | IDO1YTHDC1EGLN1 | |
| SCHEMBL6179524 | 0.82 | MAPK8 (0.56) | IDO1MAPK10YTHDC1ABHD6MAPK8 | |
| SCHEMBL6247623 | 0.81 | IDO1 (0.48) | IDO1MAPK10YTHDC1ABHD6MAPK8 | |
| SCHEMBL2116294 | 0.76 | IDO1 (0.44) | IDO1MAPK10YTHDC1ABHD6MAPK8 | |
| SCHEMBL4389849 | 0.74 | MAPK14 (0.67) | IDO1MAPK10MAPK8OPRD1MAPT | |
| SCHEMBL29779016 | 0.74 | IDO1 (0.54) | IDO1MAPK10YTHDC1ABHD6MAPK8 | |
| SCHEMBL29779014 | 0.74 | ROCK2 (0.45) | IDO1MAPK10YTHDC1ABHD6MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |