Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.46 |
| ▸ | GRK2 | P25098 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778992 | 1.00 | MMP13 (0.46) | MMP13GRK2ROCK2ROCK1LMNA | |
| SCHEMBL24617396 | 0.95 | GRK2 (0.47) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL30656464 | 0.93 | METAP2 (0.45) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL24617393 | 0.93 | METAP2 (0.45) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL24617501 | 0.89 | GRK2 (0.46) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL24617402 | 0.88 | GRK2 (0.44) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL29136007 | 0.88 | ROCK1 (0.48) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL24617357 | 0.86 | ROCK1 (0.48) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL24617503 | 0.85 | GRK2 (0.43) | MMP13GRK2ROCK2ROCK1GRK1 | |
| SCHEMBL24617504 | 0.84 | GRK2 (0.43) | MMP13GRK2ROCK2ROCK1GRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |