Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778620 | 1.00 | LMNA (0.40) | LMNATP53RXFP1POLBMAPT | |
| SCHEMBL24617487 | 0.85 | LMNA (0.35) | LMNATP53RXFP1KLKB1KDM4E | |
| SCHEMBL24617245 | 0.84 | ROCK2 (0.42) | LMNATP53RXFP1POLBKLKB1 | |
| SCHEMBL24617482 | 0.84 | LMNA (0.40) | LMNATP53RXFP1POLBMAPT | |
| SCHEMBL29778515 | 0.84 | BRAF (0.41) | LMNATP53KLKB1MAP4K1ROCK2 | |
| SCHEMBL24617486 | 0.84 | BRAF (0.41) | LMNATP53KLKB1MAP4K1ROCK2 | |
| SCHEMBL24616955 | 0.83 | MAPK1 (0.39) | LMNATP53RXFP1MAPTKLKB1 | |
| SCHEMBL24617467 | 0.82 | LMNA (0.37) | LMNAPOLBKLKB1MAP4K1ROCK2 | |
| SCHEMBL29778413 | 0.82 | LMNA (0.37) | LMNAPOLBKLKB1MAP4K1ROCK2 | |
| SCHEMBL24617627 | 0.79 | ROCK2 (0.42) | LMNAPDPK1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |