Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 9/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778509 | 1.00 | WDR5 (0.45) | WDR5PDGFRAS1PR3P2RX7KLKB1 | |
| SCHEMBL24616905 | 0.91 | PDGFRA (0.43) | WDR5PDGFRAS1PR3KLKB1KLK1 | |
| SCHEMBL31232267 | 0.91 | PDGFRA (0.43) | WDR5PDGFRAS1PR3KLKB1KLK1 | |
| SCHEMBL24616954 | 0.86 | P2RX7 (0.43) | WDR5S1PR3P2RX7 | |
| SCHEMBL29778402 | 0.85 | KDM4E (0.40) | WDR5PDGFRAS1PR3P2RX7 | |
| SCHEMBL24616874 | 0.85 | KDM4E (0.40) | WDR5PDGFRAS1PR3P2RX7 | |
| SCHEMBL30656453 | 0.84 | WDR5 (0.39) | WDR5KLKB1KLK1LMNATP53 | |
| SCHEMBL24617097 | 0.84 | WDR5 (0.39) | WDR5KLKB1KLK1LMNATP53 | |
| SCHEMBL24617629 | 0.82 | AKT1 (0.39) | WDR5P2RX7KLKB1 | |
| SCHEMBL29778999 | 0.82 | AKT1 (0.39) | WDR5P2RX7KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |