Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.43 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778607 | 0.92 | BRD4 (0.46) | PARP1MAP1LC3BMAP1LC3AROCK2MAPK10 | |
| SCHEMBL24617628 | 0.92 | BRD4 (0.46) | PARP1MAP1LC3BMAP1LC3AROCK2MAPK10 | |
| SCHEMBL29778567 | 0.92 | MAP1LC3B (0.44) | MAP1LC3BMAP1LC3AROCK2ROCK1BRD4 | |
| SCHEMBL24616895 | 0.92 | MAP1LC3B (0.44) | MAP1LC3BMAP1LC3AROCK2ROCK1BRD4 | |
| SCHEMBL29778468 | 0.91 | MAP1LC3B (0.47) | PARP1MAP1LC3BMAP1LC3AROCK2ROCK1 | |
| SCHEMBL24616892 | 0.91 | MAP1LC3B (0.47) | PARP1MAP1LC3BMAP1LC3AROCK2ROCK1 | |
| SCHEMBL29778658 | 0.90 | MAP1LC3B (0.43) | PARP1MAP1LC3BMAP1LC3AROCK2ROCK1 | |
| SCHEMBL24616896 | 0.90 | MAP1LC3B (0.43) | PARP1MAP1LC3BMAP1LC3AROCK2ROCK1 | |
| SCHEMBL24617629 | 0.90 | AKT1 (0.39) | PIM1PPARGROCK2ROCK1FLT3 | |
| SCHEMBL29778999 | 0.90 | AKT1 (0.39) | PIM1PPARGROCK2ROCK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |