Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.43 |
| ▸ | MAP1LC3A | Q9H492 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778658 | 1.00 | MAP1LC3B (0.43) | MAP1LC3BMAP1LC3AROCK2ROCK1CTSV | |
| SCHEMBL24616895 | 0.92 | MAP1LC3B (0.44) | MAP1LC3BMAP1LC3AROCK2ROCK1CTSV | |
| SCHEMBL29778567 | 0.92 | MAP1LC3B (0.44) | MAP1LC3BMAP1LC3AROCK2ROCK1CTSV | |
| SCHEMBL29778468 | 0.92 | MAP1LC3B (0.47) | MAP1LC3BMAP1LC3AROCK2ROCK1CTSV | |
| SCHEMBL24616892 | 0.92 | MAP1LC3B (0.47) | MAP1LC3BMAP1LC3AROCK2ROCK1CTSV | |
| SCHEMBL24617628 | 0.90 | BRD4 (0.46) | MAP1LC3BMAP1LC3AROCK2DRD2DRD3 | |
| SCHEMBL24617640 | 0.90 | PARP1 (0.43) | MAP1LC3BMAP1LC3AROCK2ROCK1CTSV | |
| SCHEMBL29778607 | 0.90 | BRD4 (0.46) | MAP1LC3BMAP1LC3AROCK2DRD2DRD3 | |
| SCHEMBL24616908 | 0.87 | DRD2 (0.46) | MAP1LC3BMAP1LC3AROCK2ROCK1DRD2 | |
| SCHEMBL24616898 | 0.87 | DRD2 (0.46) | MAP1LC3BMAP1LC3AROCK2ROCK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |