SCHEMBL24619490

SCHEMBL24619490

CNC(=O)c1ccc(-c2cn3c(n2)sc2cc(C(=O)NC4CCNC4)ccc23)cc1

nearest known ligand 0.65

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.65
▸ MAPT P10636 8/20 0.63
▸ TP53 P04637 4/20 0.63
▸ THRB P10828 2/20 0.63
▸ RXFP1 Q9HBX9 3/20 0.62
▸ POLB P06746 1/20 0.62
▸ ALDH1A1 P00352 3/20 0.56
▸ KDM4E B2RXH2 2/20 0.56
▸ NPC1 O15118 1/20 0.56
▸ ATM Q13315 1/20 0.56
▸ HPGD P15428 2/20 0.56
▸ ALOX15 P16050 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24619496 1.00 LMNA (0.65) LMNAMAPTTP53THRBRXFP1
SCHEMBL24619499 0.95 LMNA (0.68) LMNAMAPTTP53THRBRXFP1
SCHEMBL24619447 0.95 LMNA (0.70) LMNAMAPTTP53THRBRXFP1
Formic Acid SCHEMBL30537876 0.92 LMNA (0.64) LMNAMAPTTP53THRBRXFP1
SCHEMBL24619493 0.88 LMNA (0.79) LMNAMAPTTP53THRBRXFP1
SCHEMBL24741792 0.86 LMNA (0.61) LMNAMAPTTP53THRBRXFP1
SCHEMBL30085892 0.86 LMNA (0.61) LMNAMAPTTP53THRBRXFP1
SCHEMBL24619787 0.86 LMNA (0.61) LMNAMAPTTP53THRBRXFP1
SCHEMBL24619278 0.85 LMNA (0.67) LMNAMAPTTP53THRBRXFP1
SCHEMBL24619335 0.85 LMNA (0.67) LMNAMAPTTP53THRBRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022150316-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-07-14 — — WO disclosed
Send feedback