Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | WDR5 | P61964 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29808543 | 1.00 | GRM4 (0.44) | GRM4WDR5GRIN2AGRIN1ALDH1A1 | |
| SCHEMBL24620569 | 0.91 | EPHX2 (0.39) | GRM4WDR5GRIN2AGRIN1ALDH1A1 | |
| SCHEMBL29808368 | 0.91 | EPHX2 (0.39) | GRM4WDR5GRIN2AGRIN1ALDH1A1 | |
| SCHEMBL29808151 | 0.91 | P2RX3 (0.42) | WDR5GRIN2AGRIN1 | |
| SCHEMBL22588442 | 0.91 | P2RX3 (0.42) | WDR5GRIN2AGRIN1 | |
| SCHEMBL29808176 | 0.88 | ALDH1A1 (0.46) | WDR5GRIN2AGRIN1ALDH1A1NPC1 | |
| SCHEMBL22588976 | 0.88 | ALDH1A1 (0.46) | WDR5GRIN2AGRIN1ALDH1A1NPC1 | |
| SCHEMBL24620645 | 0.85 | GRIN2A (0.53) | GRM4WDR5GRIN2AGRIN1 | |
| SCHEMBL29808041 | 0.85 | GRIN2A (0.53) | GRM4WDR5GRIN2AGRIN1 | |
| SCHEMBL22588864 | 0.85 | GRM4 (0.46) | GRM4WDR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113692405-A | Derivatives of N- ((heteroaryl) methyl) -1-tosyl-1H-pyrazole-3-carboxamide as KV3 potassium channel activators for the treatment of neurological or psychiatric disorders | H.隆德贝克有限公司 | 2021-11-23 | — | — | CN | claimed |
| US-20220220095-A1 | N-((HETEROARYL)METHYL)-1-TOSYL-1H-PYRAZOLE-3-CARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H LUNDBECK AS (DK) | 2022-07-14 | — | — | US | disclosed |
| CN-113692405-A | Derivatives of N- ((heteroaryl) methyl) -1-tosyl-1H-pyrazole-3-carboxamide as KV3 potassium channel activators for the treatment of neurological or psychiatric disorders | H.隆德贝克有限公司 | 2021-11-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220095-A1 | N-((HETEROARYL)METHYL)-1-TOSYL-1H-PYRAZOLE-3-CARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | KCNA3, KCNK3, KCND3 | GRM4 498/4885WDR5 2499/4885GRIN2A 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.