Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 10/20 | 0.38 |
| ▸ | KRAS | P01116 | 9/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CD38 | P28907 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24625447 | 0.88 | SOS1 (0.37) | SOS1KRASLMNACD38EGFR | |
| SCHEMBL24625149 | 0.86 | SOS1 (0.46) | SOS1KRASLMNAKMT2AEGFR | |
| SCHEMBL24625384 | 0.86 | SOS1 (0.37) | SOS1KRASLMNACD38EGFR | |
| SCHEMBL24625607 | 0.84 | SOS1 (0.41) | SOS1KRASLMNACD38EGFR | |
| SCHEMBL24625393 | 0.81 | EGFR (0.40) | SOS1KRASLMNACD38EGFR | |
| SCHEMBL24625210 | 0.81 | CD38 (0.36) | SOS1KRASLMNACD38EGFR | |
| SCHEMBL24625534 | 0.81 | PIK3C2B (0.37) | SOS1KRASLMNACD38EGFR | |
| SCHEMBL25020745 | 0.80 | SOS1 (0.40) | SOS1KRASCD38CYP3A4P2RX7 | |
| SCHEMBL24602837 | 0.80 | SOS1 (0.44) | SOS1KRASLMNAEGFRUSP1 | |
| SCHEMBL24625163 | 0.79 | EGFR (0.39) | SOS1KRASLMNACD38EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148442-A1 | 6-SUBSTITUTED PHOSPHORYL QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-07-14 | — | — | WO | disclosed |