Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24625441 | 0.84 | SOS1 (0.38) | SOS1LMNAUSP1WDR48EGFR | |
| SCHEMBL24625281 | 0.84 | SOS1 (0.37) | SOS1LMNAUSP1WDR48EGFR | |
| SCHEMBL24625447 | 0.84 | SOS1 (0.37) | SOS1LMNAEGFRCYP3A4CD38 | |
| SCHEMBL24625393 | 0.83 | EGFR (0.40) | SOS1LMNAEGFRTSHRHTT | |
| SCHEMBL24625149 | 0.82 | SOS1 (0.46) | SOS1LMNAEGFRTSHRHTT | |
| SCHEMBL24625163 | 0.81 | EGFR (0.39) | SOS1LMNAEGFRTSHRHTT | |
| SCHEMBL24625210 | 0.80 | CD38 (0.36) | SOS1LMNAEGFRCYP3A4ACP1 | |
| SCHEMBL24625534 | 0.80 | PIK3C2B (0.37) | SOS1LMNAEGFRTSHRHTT | |
| SCHEMBL24802560 | 0.80 | CD38 (0.46) | SOS1LMNAPDE5AUSP1WDR48 | |
| SCHEMBL25020745 | 0.80 | SOS1 (0.40) | SOS1CYP3A4CD38P2RX7KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148442-A1 | 6-SUBSTITUTED PHOSPHORYL QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-07-14 | — | — | WO | disclosed |