Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24625379 | 0.87 | EGFR (0.45) | EGFRMAPK9MAPK10AURKAMAPK8 | |
| SCHEMBL18832756 | 0.83 | EGFR (0.46) | EGFRMAPK9MAPK10AURKAMAPK8 | |
| SCHEMBL29000700 | 0.80 | KMT2A (0.49) | EGFRMAPK10 | |
| SCHEMBL2061296 | 0.80 | EGFR (0.51) | EGFRMAPK9MAPK10MAPK8CDK9 | |
| SCHEMBL30379643 | 0.80 | KMT2A (0.49) | EGFRMAPK10 | |
| SCHEMBL24625596 | 0.76 | CDK9 (0.39) | EGFRMAPK9AURKAMAPK8CDK9 | |
| SCHEMBL24625390 | 0.74 | MEN1 (0.43) | EGFRMAPK9MAPK10MAPK8CDK9 | |
| SCHEMBL24625780 | 0.74 | AURKA (0.44) | EGFRMAPK10AURKAMAPK8ALK | |
| SCHEMBL24625395 | 0.74 | PKM (0.41) | EGFRMAPK10AURKAMAPK8PIM1 | |
| SCHEMBL30757908 | 0.74 | MEN1 (0.43) | EGFRMAPK9MAPK10MAPK8CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147620-A1 | THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |