Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 16/20 | 0.56 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179763 | 1.00 | PRMT5 (0.56) | PRMT5WDR77ADKPI4KAPI4K2B | |
| SCHEMBL18009856 | 0.89 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL24146332 | 0.83 | PRMT5 (0.79) | PRMT5WDR77ADK | |
| SCHEMBL18009767 | 0.83 | PRMT5 (0.52) | PRMT5WDR77 | |
| SCHEMBL18205093 | 0.82 | PRMT5 (0.69) | PRMT5WDR77 | |
| SCHEMBL24179761 | 0.80 | PRMT5 (0.43) | PRMT5WDR77ADKPI4KAPI4K2B | |
| SCHEMBL18009745 | 0.79 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL20475647 | 0.78 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL20475648 | 0.78 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL31526134 | 0.78 | PI4KA (0.66) | PRMT5WDR77ADKPI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174539-A1 | Substituted Pyrrolo[2,3-D]Pyrimidines As Inhibitors Of Protein Arginine Methyl Transferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2023-06-08 | — | — | US | disclosed |
| US-20230174539-A1 | Substituted Pyrrolo[2,3-D]Pyrimidines As Inhibitors Of Protein Arginine Methyl Transferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2023-06-08 | — | — | US | disclosed |
| US-11524962-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2022-12-13 | — | — | US | disclosed |
| US-20220218732-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2022-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220218732-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRMT5, PRMT6, PRMT1 | PRMT5 1/4885WDR77 52/4885ADK 2078/4885 |
| US-11524962-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5) | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 113/4885ADK 1138/4885 |
| US-20230174539-A1 | Substituted Pyrrolo[2,3-D]Pyrimidines As Inhibitors Of Protein Arginine Methyl Transferase 5 (PRMT5) | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 112/4885ADK 1154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.