Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.45 |
| ▸ | CCR5 | P51681 | 4/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
| ▸ | ADCY10 | Q96PN6 | 2/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465055 | 0.89 | CCR2 (0.50) | CCR2CCR5ALKBH3ADCY10PNP | |
| SCHEMBL2456143 | 0.87 | CCR2 (0.52) | CCR2CCR5ALKBH3ADCY10PNP | |
| SCHEMBL2460787 | 0.87 | CCR2 (0.44) | CCR2CCR5ALKBH3ADCY10PNP | |
| SCHEMBL2458554 | 0.85 | CCR2 (0.53) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2459960 | 0.84 | CCR2 (0.46) | CCR2CCR5ALKBH3ADCY10PNP | |
| SCHEMBL2459259 | 0.84 | CCR2 (0.51) | CCR2CCR5ALKBH3ADCY10PNP | |
| SCHEMBL2460161 | 0.82 | CCR2 (0.53) | CCR2CCR5ALKBH3ADCY10PNP | |
| SCHEMBL2462884 | 0.82 | ENPP1 (0.44) | CCR2CCR5ALKBH3 | |
| SCHEMBL2456001 | 0.79 | CCR2 (0.52) | CCR2CCR5 | |
| SCHEMBL2462840 | 0.78 | ALKBH3 (0.41) | CCR2CCR5ALKBH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |