Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.53 |
| ▸ | CCR5 | P51681 | 4/20 | 0.53 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.39 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456143 | 0.94 | CCR2 (0.52) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2465055 | 0.90 | CCR2 (0.50) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2459960 | 0.87 | CCR2 (0.46) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2460787 | 0.86 | CCR2 (0.44) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2462646 | 0.85 | CCR2 (0.45) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2459259 | 0.83 | CCR2 (0.51) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2460161 | 0.81 | CCR2 (0.53) | CCR2CCR5ALKBH3ADCY10 | |
| SCHEMBL2456001 | 0.78 | CCR2 (0.52) | CCR2CCR5 | |
| SCHEMBL2463316 | 0.73 | THRB (0.46) | CCR2ALKBH3KDM4EALDH1A1TDP1 | |
| SCHEMBL2456787 | 0.71 | CCR2 (0.43) | CCR2ALKBH3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |