Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29777973 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1NSD2SMN1; SMN2HTR1D | |
| SCHEMBL26731051 | 0.84 | KMT2A (0.69) | KDM4EALDH1A1NSD2SMN1; SMN2HTR1D | |
| SCHEMBL24627626 | 0.82 | KMT2A (0.51) | KMT2AF10SMPD1THRATHRB | |
| SCHEMBL30344364 | 0.82 | PARP1 (0.57) | KDM4EALDH1A1NSD2SMN1; SMN2HTR1D | |
| SCHEMBL24627424 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL4577517 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1NSD2SMN1; SMN2HTR1D | |
| SCHEMBL27575077 | 0.80 | F2 (0.57) | KMT2ALMNA | |
| SCHEMBL25820408 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1NSD2SMN1; SMN2HTR1D | |
| SCHEMBL29777992 | 0.78 | L3MBTL1 (0.60) | SMN1; SMN2KMT2ALMNAF10SMPD1 | |
| SCHEMBL14132260 | 0.76 | F10 (0.80) | ALDH1A1SMN1; SMN2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148879-A1 | QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF ACKR3 | STICHTING VU (NL) | 2022-07-14 | — | — | WO | disclosed |