Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772887 | 1.00 | LMNA (0.46) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL29772926 | 0.89 | ALDH1A1 (0.46) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL21244041 | 0.89 | TSHR (0.50) | LMNAHTTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL23536124 | 0.87 | TSHR (0.39) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL29931867 | 0.87 | TSHR (0.39) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL24628363 | 0.85 | LMNA (0.44) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL29772850 | 0.85 | LMNA (0.44) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL23536152 | 0.80 | LMNA (0.40) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL29931786 | 0.80 | LMNA (0.40) | LMNAHTTSMN1; SMN2TP53GAA | |
| SCHEMBL21244042 | 0.80 | ALDH1A1 (0.52) | LMNAHTTSMN1; SMN2TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150461-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. (US) | 2022-07-14 | — | — | WO | disclosed |