Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24629926 | 0.88 | LMNA (0.42) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL29769155 | 0.83 | MAPK1 (0.45) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL24629971 | 0.83 | MAPK1 (0.45) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL24629610 | 0.81 | POLB (0.41) | LMNAMAPK1KDM4EALDH1A1POLB | |
| SCHEMBL29769136 | 0.81 | POLB (0.41) | LMNAMAPK1KDM4EALDH1A1POLB | |
| SCHEMBL29769220 | 0.81 | KMT2A (0.46) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL24629608 | 0.81 | KMT2A (0.46) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL29769080 | 0.79 | GFER (0.38) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL24630132 | 0.79 | GFER (0.38) | LMNAMAPK1KMT2AKDM4EHSD17B10 | |
| SCHEMBL29769222 | 0.79 | HCRTR1 (0.43) | MAPK1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150574-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022150574-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2022-07-14 | — | — | WO | disclosed |