Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 4/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.46 |
| ▸ | CDK8 | P49336 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30868564 | 1.00 | FEN1 (0.46) | FEN1ALOX5APCDK8BRD4TNNI3K | |
| SCHEMBL24631356 | 0.80 | TNNI3K (0.49) | BRD4TNNI3KTEAD1YAP1SCN9A | |
| SCHEMBL30868609 | 0.80 | TNNI3K (0.49) | BRD4TNNI3KTEAD1YAP1SCN9A | |
| SCHEMBL30868500 | 0.80 | TNNI3K (0.43) | TNNI3KTEAD1YAP1SCN9AMEN1 | |
| SCHEMBL24631193 | 0.80 | TNNI3K (0.43) | TNNI3KTEAD1YAP1SCN9AMEN1 | |
| SCHEMBL30868540 | 0.79 | BRD4 (0.45) | BRD4TNNI3KMEN1ALOX15MAPK1 | |
| SCHEMBL27170917 | 0.79 | BRD4 (0.45) | BRD4TNNI3KMEN1ALOX15MAPK1 | |
| SCHEMBL24631191 | 0.78 | LCK (0.45) | TEAD1YAP1SCN9A | |
| SCHEMBL30868579 | 0.78 | LCK (0.45) | TEAD1YAP1SCN9A | |
| SCHEMBL24631270 | 0.77 | TRPA1 (0.44) | BRD4TEAD1YAP1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | disclosed |
| WO-2022177869-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2022-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | FEN1 4715/4885ALOX5AP 1957/4885CDK8 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.