SCHEMBL24632147

SCHEMBL24632147

CC(C)c1cc(Cc2c(Cl)cc(OCC(O)N(C)CC(F)(F)F)cc2Cl)ccc1O

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.58
THRA P10827 19/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24632201 0.86 THRB (0.60) THRBTHRA
SCHEMBL24632149 0.82 THRB (0.71) THRBTHRA
SCHEMBL24632193 0.82 THRB (0.68) THRBTHRA
SCHEMBL21286536 0.78 THRB (0.76) THRBTHRA
SCHEMBL24132898 0.77 THRA (0.63) THRBTHRA
SCHEMBL24632143 0.76 THRB (0.74) THRBTHRA
SCHEMBL21286588 0.75 THRB (0.78) THRBTHRA
SCHEMBL21286571 0.74 THRB (0.69) THRBTHRA
SCHEMBL24132760 0.74 THRA (0.69) THRBTHRA
SCHEMBL24132793 0.74 THRA (0.65) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022236133-A1 FATTY ACID AMIDE HYDROLASE (FAAH) CLEAVABLE PRODRUGS OF THYROMIMETICS AND COMBINATION WITH PERIPHERALLY RESTRICTED FAAH INHIBITORS AUTOBAHN THERAPEUTICS, INC. (US) 2022-11-10 WO disclosed