Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.48 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.48 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.48 |
| ▸ | PNP | P00491 | 3/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KRAS | P01116 | 3/20 | 0.45 |
| ▸ | HINT1 | P49773 | 1/20 | 0.43 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20762967 | 0.90 | POLB (0.54) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL20762962 | 0.90 | POLB (0.54) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL4968018 | 0.89 | POLB (0.61) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL16144103 | 0.88 | POLB (0.56) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL21417495 | 0.88 | POLB (0.59) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL3894678 | 0.88 | POLB (0.59) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL18837841 | 0.88 | POLB (0.59) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL20758514 | 0.88 | POLB (0.59) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL26855308 | 0.88 | POLB (0.54) | POLBTGM2NT5EFUT5P2RY2 | |
| SCHEMBL24473838 | 0.88 | POLB (0.52) | POLBTGM2NT5EFUT5P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220364098-A1 | COMPOSITIONS AND METHODS FOR MODULATING PNPLA3 EXPRESSION | DICERNA PHARMACEUTICALS, INC. | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220364098-A1 | COMPOSITIONS AND METHODS FOR MODULATING PNPLA3 EXPRESSION | PNPLA2, PNLIP, PLAAT3 | POLB 641/4885TGM2 1116/4885NT5E 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.