Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cinnamaldehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.78 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | CCND1 | P24385 | 2/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cinnamaldehyde SCHEMBL2463425 | 1.00 | ALDH1A1 (0.78) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL27979522 | 0.96 | ALDH1A1 (0.78) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL27979524 | 0.96 | ALDH1A1 (0.78) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL29206156 | 0.91 | ALDH1A1 (0.86) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL29206157 | 0.91 | ALDH1A1 (0.86) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL28987536 | 0.90 | ALDH1A1 (0.69) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL5414560 | 0.89 | ALDH1A1 (0.90) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL25267814 | 0.89 | ALDH1A1 (1.00) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL3442 | 0.89 | ALDH1A1 (1.00) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamic Aldehyde SCHEMBL159856 | 0.89 | ALDH1A1 (1.00) | ALDH1A1LMNATRPA1ALOX5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114347-A2 | SYNERGISTIC EFFECT OF NETURAL COMPOUND AS A FUNGICIDE AND BACTERICIDE FOR AGRICULTURE CROP ESPECIALLY CUMIN CROP. | BALAR CHETAN (IN) | 2011-09-22 | — | — | WO | claimed |
| US-20230049807-A1 | PHARMACEUTICAL COMPOSITION COMPRISING TRANS - CINNAMALDEHYDE AND ITS USE IN THE TREATMENT OF INFECTIONS | SEPTEOS (FR) | 2023-02-16 | — | — | US | disclosed |
| US-11497720-B2 | Pharmaceutical composition comprising trans-cinnamaldehyde and its use in the treatment of infections | SEPTEOS (FR) | 2022-11-15 | — | — | US | disclosed |
| CN-113474324-A | Isobutyrate compounds having n-butyryloxy group at alpha position, fragrance compositions and use as fragrance | 三菱瓦斯化学株式会社 | 2021-10-01 | — | — | CN | disclosed |
| US-10864188-B2 | Anti-microbial composition | SEPTEOS (FR) | 2020-12-15 | — | — | US | disclosed |
| CN-110917258-A | Foot bath cream for improving yang and preparation process thereof | 杭州青蜓遵序堂健康管理有限公司 | 2020-03-27 | — | — | CN | disclosed |
| CN-110711233-A | Traditional Chinese medicine composition, medicinal liquor and decoction for conditioning sub-health | 迪国生物高科技有限公司 | 2020-01-21 | — | — | CN | disclosed |
| CN-110613810-A | Traditional Chinese medicine composition for conditioning sub-health and preparation method thereof | 迪国生物高科技有限公司 | 2019-12-27 | — | — | CN | disclosed |
| EP-2648704-B1 | ANTI-MICROBIAL COMPOSITION | SEPTEOS (FR) | 2019-01-16 | — | — | EP | disclosed |
| US-20170000762-A1 | ANTI-MICROBIAL COMPOSITION | SEPTEOS (FR) | 2017-01-05 | — | — | US | disclosed |
| US-20130289103-A1 | ANTI-MICROBIAL COMPOSITION | SEPTEOS (FR) | 2013-10-31 | — | — | US | disclosed |
| EP-2648704-A1 | ANTI-MICROBIAL COMPOSITION | Septeos (FR) | 2013-10-16 | — | — | EP | disclosed |
| EP-2648703-A1 | PHARMACEUTICAL COMPOSITION COMPRISING TRANS-CINNAMALDEHYDE AND ITS USE IN THE TREATMENT OF INFECTIONS | Septeos (FR) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076717-A1 | PHARMACEUTICAL COMPOSITION COMPRISING TRANS-CINNAMALDEHYDE AND ITS USE IN THE TREATMENT OF INFECTIONS | SOCIETE DE DEVELOPPEMENT SCIENTIFIQUE - SDS (FR) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012076718-A1 | ANTI-MICROBIAL COMPOSITION | SOCIETE DE DEVELOPPEMENT SCIENTIFIQUE - SDS (FR) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011114347-A3 | COMPOSITION COMPRISING A NATURAL FUNGICIDE AND A NATURAL BAVERICIDE FOR AGRICULTURAL USE | BALAR CHETAN (IN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011114347-A2 | SYNERGISTIC EFFECT OF NETURAL COMPOUND AS A FUNGICIDE AND BACTERICIDE FOR AGRICULTURE CROP ESPECIALLY CUMIN CROP. | BALAR CHETAN (IN) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114347-A2 | SYNERGISTIC EFFECT OF NETURAL COMPOUND AS A FUNGICIDE AND BACTERICIDE FOR AGRICULTURE CROP ESPECIALLY CUMIN CROP. | BALAR CHETAN (IN) | 2011-09-22 | — | — | WO | disclosed |
| WO-2007062414-A1 | HYDROGEL SHEETS AND SHAPES FOR ORAL CARE | GRINRX (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2003000016-A2 | HIGHLY CONCENTRATED ORGANIC COMPOUND EMULSIONS AND METHODS OF USE | THE BANKS GROUP, LLC (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11497720-B2 | Pharmaceutical composition comprising trans-cinnamaldehyde and its use in the treatment of infections | PIGS, MANBA, PIGT | ALDH1A1 453/4885LMNA 1482/4885TRPA1 128/4885 |
| US-20230049807-A1 | PHARMACEUTICAL COMPOSITION COMPRISING TRANS - CINNAMALDEHYDE AND ITS USE IN THE TREATMENT OF INFECTIONS | PIGS, MANBA, PIGT | ALDH1A1 453/4885LMNA 1482/4885TRPA1 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.