Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 4/20 | 0.35 |
| ▸ | CCND1 | P24385 | 4/20 | 0.35 |
| ▸ | CCND2 | P30279 | 3/20 | 0.35 |
| ▸ | CCND3 | P30281 | 3/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466503 | 0.78 | AVPR1B (0.42) | IDO1TDO2IDO2PDE7APDE7B | |
| SCHEMBL12334743 | 0.77 | AVPR1B (0.42) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4060343 | 0.70 | HTR1A (0.43) | HTR1AHTR7HTR2B | |
| SCHEMBL3056004 | 0.65 | ENPP2 (0.47) | — | |
| SCHEMBL5804762 | 0.65 | MAPK14 (0.44) | — | |
| SCHEMBL2462426 | 0.65 | AVPR1B (0.60) | — | |
| SCHEMBL2462438 | 0.63 | AVPR1B (0.44) | — | |
| SCHEMBL296197 | 0.60 | ENPP2 (0.49) | — | |
| SCHEMBL30202377 | 0.60 | ENPP2 (0.49) | — | |
| SCHEMBL1919522 | 0.60 | ENPP2 (0.44) | IDO1TDO2IDO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069315-B1 | QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES | ORGANON NV (NL) | 2011-09-07 | — | — | EP | disclosed |