Sugi Predict

Sugi Predict / Compounds / SCHEMBL2463538

SCHEMBL2463538

SCHEMBL2463538

N[N+]12C=CN=CC1=C(C1=CC=C1)N=C2c1cccc(OCc2ccccc2)c1F

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 1/20 0.33
▸ PTGER1 P34995 1/20 0.31
▸ PDE5A O76074 1/20 0.31
▸ PDE4A P27815 1/20 0.31
▸ PDE4B Q07343 1/20 0.31
▸ PDE4C Q08493 1/20 0.31
▸ PDE4D Q08499 1/20 0.31
▸ KDM1A O60341 2/20 0.30
▸ BRD4 O60885 1/20 0.30
▸ LTA4H P09960 1/20 0.30
▸ MAPK14 Q16539 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ MAPK1 P28482 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30
▸ L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2457091 0.87 MRGPRX4 (0.33) DHODHPTGER1BRD4MAPTMAPK1
SCHEMBL2458336 0.83 KDM4C (0.32) PTGER1KDM1A
SCHEMBL4361839 0.79 TNK2 (0.30) —
SCHEMBL2459494 0.79 KDR (0.35) —
SCHEMBL2460481 0.79 PDE4A (0.39) PDE4APDE4BPDE4CPDE4DMAPT
SCHEMBL2457080 0.78 MEN1 (0.39) MAPTTDP1L3MBTL1
SCHEMBL2460708 0.78 KDM4E (0.35) MAPTMAPK1TDP1L3MBTL1
SCHEMBL2460343 0.77 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
SCHEMBL2459539 0.76 MRGPRX4 (0.30) DHODH
SCHEMBL2462348 0.74 IGF1R (0.34) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 DHODH 3525/4885PTGER1 3389/4885PDE5A 1016/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 DHODH 3525/4885PTGER1 3389/4885PDE5A 1016/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 DHODH 3525/4885PTGER1 3389/4885PDE5A 1016/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.