Sugi Predict

Sugi Predict / Compounds / SCHEMBL2457091

SCHEMBL2457091

SCHEMBL2457091

Fc1c(OCc2ccccc2)cccc1C1=NC(C2=CC=C2)=C2C=NC=C[N+]12Cl

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MRGPRX4 Q96LA9 2/20 0.33
▸ PTGER1 P34995 5/20 0.33
▸ DHODH Q02127 1/20 0.33
▸ IDO1 P14902 1/20 0.31
▸ BRD4 O60885 1/20 0.30
▸ L3MBTL1 Q9Y468 2/20 0.30
▸ LMNA P02545 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30
▸ NCOA3 Q9Y6Q9 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ MAPK1 P28482 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2463538 0.87 DHODH (0.33) PTGER1DHODHBRD4L3MBTL1MAPT
SCHEMBL2461373 0.83 MRGPRX4 (0.32) MRGPRX4PTGER1
SCHEMBL2458350 0.80 MRGPRX4 (0.38) MRGPRX4DHODHLMNASMN1; SMN2MAPK1
SCHEMBL2460034 0.78 KDM4E (0.37) MRGPRX4PTGER1L3MBTL1LMNASMN1; SMN2
SCHEMBL2461788 0.77 PDE4A (0.32) —
SCHEMBL2458336 0.72 KDM4C (0.32) MRGPRX4PTGER1
SCHEMBL2462727 0.72 KMO (0.30) —
SCHEMBL2459494 0.70 KDR (0.35) —
SCHEMBL2460708 0.67 KDM4E (0.35) MRGPRX4L3MBTL1LMNASMN1; SMN2MAPT
SCHEMBL2457080 0.67 MEN1 (0.39) MRGPRX4L3MBTL1LMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 MRGPRX4 1767/4885PTGER1 3389/4885DHODH 3525/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 MRGPRX4 1767/4885PTGER1 3389/4885DHODH 3525/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 MRGPRX4 1767/4885PTGER1 3389/4885DHODH 3525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.