Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246701 | 0.84 | PIN1 (0.46) | MEN1KMT2AALDH1A1TDP1PIN1 | |
| SCHEMBL248604 | 0.76 | PDE1B (0.42) | MEN1KMT2AALDH1A1TDP1KDM4E | |
| SCHEMBL11983744 | 0.75 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1TDP1TUBB4A | |
| SCHEMBL246386 | 0.74 | PDGFRB (0.50) | ALDH1A1PDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL22410696 | 0.72 | MEN1 (0.59) | MEN1KMT2AALDH1A1TDP1KDM4E | |
| SCHEMBL6973058 | 0.72 | ALDH1A1 (0.52) | KMT2AALDH1A1TDP1TUBB4ATUBB | |
| SCHEMBL4466194 | 0.71 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1TDP1TUBB4A | |
| SCHEMBL8377814 | 0.71 | ALDH1A1 (0.55) | KMT2AALDH1A1TDP1TUBB4ATUBB | |
| SCHEMBL31077739 | 0.71 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1TDP1TUBB4A | |
| SCHEMBL24716663 | 0.71 | KMT2A (0.50) | MEN1KMT2AALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588457-B1 | PYRAZOLOQUINOLINE DERIVATIVES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-05 | — | — | EP | disclosed |
| EP-2588457-A1 | PYRAZOLO-QUINOLINES | Merck Patent GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012000632-A1 | PYRAZOLO-QUINOLINES | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |