Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 13/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640209 | 1.00 | TIPARP (0.34) | TIPARPAXLIDH1ACACBOGA | |
| SCHEMBL24639265 | 1.00 | TIPARP (0.34) | TIPARPAXLIDH1ACACBOGA | |
| SCHEMBL24640612 | 0.83 | AXL (0.36) | TIPARPAXLPARP1CYP2C9CYP2C19 | |
| SCHEMBL24639266 | 0.83 | TIPARP (0.35) | TIPARPAXLACACBOGAPARP1 | |
| SCHEMBL24639247 | 0.83 | TIPARP (0.35) | TIPARPAXLACACBOGAPARP1 | |
| SCHEMBL24639272 | 0.82 | AXL (0.36) | TIPARPAXL | |
| SCHEMBL24639284 | 0.82 | AXL (0.36) | TIPARPAXL | |
| SCHEMBL24639256 | 0.82 | AXL (0.36) | TIPARPAXL | |
| SCHEMBL24640710 | 0.82 | DRD2 (0.34) | TIPARPAXL | |
| SCHEMBL24640309 | 0.82 | TIPARP (0.48) | TIPARPPARP1CYP2C9CYP2C19PARP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |