Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12327177 | 0.80 | DYRK1A (0.66) | CDC7CDK2DYRK1AGSK3BNLRP3 | |
| SCHEMBL2464056 | 0.78 | DYRK1A (0.57) | CDC7CDK2DYRK1AGSK3BACVR1 | |
| SCHEMBL12327008 | 0.75 | DYRK1A (0.47) | CDC7CDK2DYRK1AGSK3BKCNH2 | |
| SCHEMBL18976877 | 0.74 | DYRK1A (0.46) | CDC7CDK2DYRK1AGSK3BKCNH2 | |
| SCHEMBL1648134 | 0.71 | CYP4F2 (0.41) | ALDH1A1GAAMAPTAKT1RXRA | |
| SCHEMBL2464307 | 0.71 | DYRK1A (0.43) | CDC7CDK2DYRK1AGSK3BKCNH2 | |
| SCHEMBL2468525 | 0.69 | DYRK1A (0.50) | CDC7CDK2DYRK1AGSK3BNLRP3 | |
| SCHEMBL27926310 | 0.67 | DYRK1A (0.39) | CDC7CDK2DYRK1AGSK3BKCNH2 | |
| SCHEMBL12327702 | 0.66 | PRKCG (0.49) | HPGD | |
| SCHEMBL29281211 | 0.66 | METAP2 (0.34) | ACVRL1ACVR1ALDH1A1HPGDYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547677-A2 | INHIBITORS OF SEMICARABAZIDE - SENSITIVE AMINE OXIDASE | Proximagen Limited (GB) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113798-A2 | NEW ENZYME INHIBITOR COMPOUNDS | PROXIMAGEN LIMITED (GB) | 2011-09-22 | — | — | WO | disclosed |